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Alkaline phosphatase in stem cells

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ŠTEFKOVÁ Kateřina PROCHÁZKOVÁ Jiřina PACHERNÍK Jiří

Rok publikování 2015
Druh Článek v odborném periodiku
Časopis / Zdroj Stem Cells International
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www http://dx.doi.org/10.1155/2015/628368
Doi http://dx.doi.org/10.1155/2015/628368
Obor Genetika a molekulární biologie
Klíčová slova alkaline phosphatase; stem cell; MSC; ESC
Popis Alkaline phosphatase is an enzyme commonly expressed in almost all living organisms. In humans and other mammals, determinations of the expression and activity of alkaline phosphatase have frequently been used for cell determination in developmental studies and/or within clinical trials. Alkaline phosphatase also seems to be one of the key markers in the identification of pluripotent embryonic stem as well as related cells. However, alkaline phosphatases exist in some isoenzymes and isoforms, which have tissue specific expressions and functions. Here, the role of alkaline phosphatase as a stem cell marker is discussed in detail. First, we briefly summarize contemporary knowledge of mammalian alkaline phosphatases in general. Second, we focus on the known facts of its role in and potential significance for the identification of stem cells.
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