Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes polymorphisms in multiple sclerosis.
|Year of publication||2007|
|Type||Article in Periodical|
|Magazine / Source||Journal of Neurology|
|MU Faculty or unit|
|Field||Neurology, neurosurgery, neurosciences|
|Keywords||multiple sclerosis;MMP-2;TIMP-2 genes polymorphisms|
|Description||Multiple sclerosis (MS) is a multifactorial, polygenic disease. Matrix metalloproteinases (MMPs) play an important role in the immunopathogenesis and progression of MS.The aim of this study was to examine possible association among polymorphisms in gene promotor region for MMP-2 (-168G/T, -735C/T, -790T/G, -1306C/T) and TIMP-2 (+853 G/A, -418 G/C) with multiple sclerosis. Methods: A sample of 221 patients with multiple sclerosis was compared to 118 healthy subjects.The DNA genotyping was performed using PCR methods with restriction analyses.According to our results, distribution of polymorphisms in MMP-2 (-735C/T) and TIMP-2 (+853)G/A gene are associated with higher risk for relapsing-remitting multiple sclerosis clinical manifestation.|