Publication details

Haplotype analysis of the endothelial nitric oxide synthase (eNOS) gene in asthma

Authors

IZAKOVIČOVÁ HOLLÁ Lydie JURAJDA Michal POHUNEK Petr ZNOJIL Vladimír

Year of publication 2008
Type Article in Periodical
Magazine / Source Hum Immunol
MU Faculty or unit

Faculty of Medicine

Citation
Field Epidemiology, infectious diseases and clinical immunology
Keywords asthma; gene; nitric oxide synthase; NOS3; polymorphisms
Description Nitric oxide (NO) is an important mediator of physiologic processes in the airways. There is evidence that genetic factors affect NO formation and contribute to the pathophysiology of asthma. The aims of this study were to determine the eNOS haplotypes in Czech asthmatics and control subjects and to examine their relation to asthma. Our findings suggest that endothelial NOS variants may be one of the factors participating in protection or susceptibility to asthma in our population.
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