Publication details

Correlation of gene expression with centrosome amplification in multiple myeloma

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ŠEVČÍKOVÁ Sabina KRYUKOV Fedor DEMENTYEVA Elena Vladimirovna NĚMEC Pavel HÁJEK Roman

Year of publication 2011
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Description Centrosome amplification (CA) may lead to genomic instability of malignant plasma cells in multiple myeloma (MM). Study objective was to evaluate association of CA with expression of genes controlling centrosome duplication. In this study, we showed close interaction between presence of CA and expression of genes controlling centrosome duplication (PCNT, AURKB, AURKA, CCNB2, PLK4, HMMR, TACC3). Some of these genes (AURKA, PCNT and TACC3) reflect even CA positivity of patients.
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