Publication details

Impact of Nestin Analysis in Multiple Myeloma

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Authors

ŠVÁCHOVÁ Hana KOVÁŘOVÁ Lucie ŠTOSSOVÁ Jana POTÁČOVÁ Anna POUR Luděk HÁJEK Roman

Year of publication 2011
Type Article in Periodical
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords nestin; plasma cells; multiple myeloma; myeloma stem cells; myeloma-initiating cells; flow cytometry
Description Nestin, a marker of multipotent precursor cells, is an important dynamic structure; its polymerization/ depolymerization influences intracellular signaling and participates in key cell processes such as proliferation, migration and cell survival. It is presumed that nestin plays a central role in carcinogenesis. It is suggested that nestin might be a suitable diagnostic and prognostic indicator of malignancy and a potential marker of cancer stem cells. Unexpectedly, nestin has been identified in mature CD138+CD38+ plasma cells (PC) of multiple myeloma patients (MM). Expression of nestin, a marker of stem/progenitor cells, in malignant PC, that are considered to be terminally differentiated, indicates that nestin might play a unique role in pathology of MM.
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