Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2018127
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
-
Institute of Biotechnology CAS
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 328
2023
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Fate of Gold Nanoparticles in Laser Desorption/Ionization Mass Spectrometry: Toward the Imaging of Individual Nanoparticles
Journal of the American Society for Mass Spectrometry, year: 2023, volume: 34, edition: 4, DOI
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Human senataxin is a bona fide R-loop resolving enzyme and transcription termination factor
Nucleic Acids Research, year: 2023, volume: 51, edition: 6, DOI
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Hydrophobicity Boosts Catalytic Activity: The Tailoring of Aluminosilicates with Trimethylsilyl Groups
ChemCatChem, year: 2023, volume: 15, edition: 13, DOI
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Characterisation of invisible conformation of domain 1.1 of σA factor of RNA polymerase from Bacillus subtilis
Year: 2023, type: Conference abstract
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Characterization of a transitionally occupied state and thermal unfolding of domain 1.1 of σ A factor of RNA polymerase from Bacillus subtilis
Proteins: Structure, Function and Bioinformatics, year: 2023, volume: 91, edition: 9, DOI
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Illuminating the mechanism and allosteric behavior of NanoLuc luciferase
Nature Communications, year: 2023, volume: 14, edition: 1, DOI
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Insight into inherited anemia CDA-I: disease-associated mutations disrupt Codanin1-CDIN1 complex
Year: 2023, type: Appeared in Conference without Proceedings
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Insight into peculiar adhesion of cells to plasma-chemically prepared multifunctional “amino-glue” surfaces
Plasma Processes and Polymers, year: 2023, volume: 20, edition: 6, DOI
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Irradiation potentiates p53 phosphorylation and p53 binding to the promoter and coding region of the TP53 gene
Biochimie, year: 2023, volume: 204, edition: January, DOI
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Membrane-Targeting Perylenylethynylphenols Inactivate Medically Important Coronaviruses via the Singlet Oxygen Photogeneration Mechanism
Molecules, year: 2023, volume: 28, edition: 17, DOI