Elevace plazmatických hladin BAFF (B-cell activating factor) u pediatrických pacientů s akutní lymfoblastickou leukémií oproti B-lymfomům

• Title in English: Elevation of B-cell activating factor (BAFF) levels in paediatric patients with acute lymphoblastic leukemia compared to other B-lineage malignancies
• Authors: BIENERTOVÁ VAŠKŮ Julie; KALINA Dale Robert; NORDHEIM Vegard Aas-Aune; ŠPLÍCHAL Zbyněk; ZLÁMAL Filip; TOMANDL Josef; TOMANDLOVÁ Marie; KODYTKOVÁ Daniela; VAŠKŮ Anna; ŠTĚRBA Jaroslav
• Year of publication: 2012
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Description: There is emerging evidence that B-lineage neoplasms have aberrant expression of B-cell activating factor (BAFF) that enables the B cells to escape apoptosis. The aim of the study therefore was to investigate circulating levels of BAFF in paediatric malignancies related to B-cell growth, i.e. B-cell acute lymphoblastic leukaemia (B-ALL) and B-lineage lymphomas. We observed significant differences in circulating levels of BAFF between the B-ALL patients and B-cell lymphoma patients, the circulating levels of BAFF being substantially higher in B-ALL cases.

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