Informace o projektu

Aberrant Splicing of CFTR Exon 9 (ASCE)

Kód projektu
630758
Období řešení
3/2014 - 2/2018
Investor/Program
Evropská unie
Programový rámec / typ projektu
7. rámcový program EU - Lidé
Fakulta/Pracoviště MU
Středoevropský technologický institut

Alternative splicing of pre-mRNAs is tightly regulated and any imbalance can change the outcome of gene expression which often leads to disease. Despite the importance of alternative splicing regulation our knowledge at the molecular level is still in its infancy hampering development of effective therapies. We plan to study the regulatory RNA-protein and proteinprotein interaction networks leading to skipping of CFTR exon 9 associated with severe forms of cystic fibrosis. Structure determination of regulatory complexes by NMR spectroscopy in combination with biochemical and functional in vivo studies will be used to deepen our molecular understanding of the regulatory networks governing the proper assembly of mRNAs. With this, we want to reveal the molecular basis of aberrant CFTR exon 9 splicing and lay a rational, structure-functionbased foundation for novel approaches to cure diseases.

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