Mechanorecepce jako mechanizmus řídící odontogenezi napříč obratlovci
- Kód projektu
- Období řešení
- 1/2022 - 12/2024
- Investor / Programový rámec / typ projektu
- Grantová agentura ČR
- Fakulta / Pracoviště MU
- Lékařská fakulta
- Spolupracující organizace
Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
Tooth development is precisely controlled system with the involvement of different pools of stem cell niches. However, the cellular mechanisms underlaying tooth growth and dental tissue repair still remain to be elusive. The main aim of this project is to determine the role of cellular mechanosensing and associated signalling in regulation of tooth growth and the contribution of these processes in the healing of dental tissues. Rodent incisors and their tooth-bone interphase area will be used as a model to study permanent grow activity and mouse molars will serves as a model of soft tissue damage leading to ankylosis. Moreover, comparison with other vertebrate species will help us to uncover if mechanosensing is a general mechanism used by all vertebrates regardless on morphology of tooth-bone area during odontogenesis. This project will help us also to understand mechanisms involved in reparative and regenerative odontogenesis and to tack more general questions extending beyond the dental field, which will provide new insight to the regulation of developmental and healing processes.