Informace o publikaci

The rDNA Loci-Intersections of Replication, Transcription, and Repair Pathways

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GOFFOVÁ Ivana FAJKUS Jiří

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj International Journal of Molecular Sciences
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www https://doi.org/10.3390/ijms22031302
Doi http://dx.doi.org/10.3390/ijms22031302
Klíčová slova rDNA organization; genome stability; rRNA genes; ribosome; CAF-1; RAD51; RTEL1
Popis Genes encoding ribosomal RNA (rDNA) are essential for cell survival and are particularly sensitive to factors leading to genomic instability. Their repetitive character makes them prone to inappropriate recombinational events arising from collision of transcriptional and replication machineries, resulting in unstable rDNA copy numbers. In this review, we summarize current knowledge on the structure and organization of rDNA, its role in sensing changes in the genome, and its linkage to aging. We also review recent findings on the main factors involved in chromatin assembly and DNA repair in the maintenance of rDNA stability in the model plants Arabidopsis thaliana and the moss Physcomitrella patens, providing a view across the plant evolutionary tree.
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