
Informace o projektu
What orangutans can teach us: plants used for self-medication as a potential source of bioactive substances with amoebicidal and antigiardial effects
- Kód projektu
- GA23-06571S
- Období řešení
- 1/2023 - 12/2025
- Investor / Programový rámec / typ projektu
-
Grantová agentura ČR
- Standardní projekty
- Fakulta / Pracoviště MU
- Přírodovědecká fakulta
- Spolupracující organizace
-
Ústav experimentální botaniky AV ČR, v. v. i.
- Odpovědná osoba Dr. Karel Doležal
- Odpovědná osoba Dr. Bohumil Sak
The main aim of this project is the isolation, identification and examination of bioactive plant compounds with potential antiparasitic activity. These extracts will be obtained from plants that are routinely eaten by orangutans. Our previous research suggests that the purpose of this consumption is self-medication. The main criteria for the plant selection are the behavioral data of the orangutans and the parasite infections thereof. The effect of these extracts on the progression of significant waterborne protozoal diseases (WBD), namely amoebiasis and giardiasis, will be tested using both in vitro and in vivo methods. The parasites spreading such diseases are a major cause of the increase in morbidity and mortality rates worldwide as these diseases are often fatal for immunocompromised people such as those with HIV. Therefore, they pose a significant world health problem with a considerable impact on the global economy. To control these diseases, the development of new and sustainable medicaments is required, to which the research of bioactive plant compounds greatly contributes.
Publikace
Počet publikací: 5
2025
-
ParasiteEffect of selected Indonesian plants on Giardiaintestinalis in an experimental in vitro modelRadka
BMC COMPLEMENTARY MEDICINE AND THERAPIES, rok: 2025, ročník: 25, vydání: 22, DOI
2024
-
Effect of selected Indonesian plants on Giardia intestinalis in experimental in vitro model
Rok: 2024, druh: Další prezentace na konferencích
-
What orangutans (Pongo spp.) can teach us: plants used for self-medication as a potential source of bioactive substances with amebicidal and antigiardial effects – project presentation with preliminary results
Rok: 2024, druh: Konferenční abstrakty
2023
-
First Study of Ascaris lumbricoides from the Semiwild Population of the Sumatran Orangutan Pongo abelii in the Context of Morphological Description and Molecular Phylogeny
Life, rok: 2023, ročník: 13, vydání: 4, DOI
-
What Orangutans Can Teach Us: Plants Used for Self-medication as a Potential Source of Bioactive Substances with Antiparasitic Effects
Rok: 2023, druh: Další prezentace na konferencích