Informace o publikaci

Previous Lung Diseases and Lung Cancer Risk: A Pooled Analysis From the International Lung Cancer Consortium

Autoři	BRENNER Darren R BOFFETTA Paolo DUELL Eric J. BICKEBOELLER Heike ROSENBERGER Albert MCCORMACK Valerie MUSCAT Joshua E. YANG Ping WICHMANN H. Erich BRUESKE-HOHLFELD Irene SCHWARTZ Ann G. COTE Michele L. TJONNELAND Anne FRIIS Soren LE MARCHAND Loic ZHANG Zuo-Feng MORGENSTERN Hal SZESZENIA-DABROWSKA Neonila LISSOWSKA Jolanta ZARIDZE David RUDNAI Peter FABIANOVA Eleonora FORETOVÁ Lenka JANOUT Vladimir BENCKO Vladimir SCHEJBALOVA Miriam BRENNAN Paul MATES Ioan N. LAZARUS Philip FIELD John K. RAJI Olaide MCLAUGHLIN John R. LIU Geoffrey WIENCKE John NERI Monica UGOLINI Donatella ANDREW Angeline S. LAN Qing HU Wei ORLOW Irene PARK Bernard J. HUNG Rayjean J.
Rok publikování	2012
Druh	Článek v odborném periodiku
Časopis / Zdroj	American journal of epidemiology
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Doi	http://dx.doi.org/10.1093/aje/kws151
Obor	Onkologie a hematologie
Klíčová slova	bronchitis; chronic; emphysema; lung diseases; lung neoplasms; meta-analysis; pneumonia; pulmonary disease; chronic obstructive; tuberculosis
Popis	To clarify the role of previous lung diseases (chronic bronchitis, emphysema, pneumonia, and tuberculosis) in the development of lung cancer, the authors conducted a pooled analysis of studies in the International Lung Cancer Consortium. Seventeen studies including 24,607 cases and 81,829 controls (noncases), mainly conducted in Europe and North America, were included (19842011). Using self-reported data on previous diagnoses of lung diseases, the authors derived study-specific effect estimates by means of logistic regression models or Cox proportional hazards models adjusted for age, sex, and cumulative tobacco smoking. Estimates were pooled using random-effects models. Analyses stratified by smoking status and histology were also conducted. A history of emphysema conferred a 2.44-fold increased risk of lung cancer (95 confidence interval (CI): 1.64, 3.62 (16 studies)). A history of chronic bronchitis conferred a relative risk of 1.47 (95 CI: 1.29, 1.68 (13 studies)). Tuberculosis (relative risk 1.48, 95 CI: 1.17, 1.87 (16 studies)) and pneumonia (relative risk 1.57, 95 CI: 1.22, 2.01 (12 studies)) were also associated with lung cancer risk. Among never smokers, elevated risks were observed for emphysema, pneumonia, and tuberculosis. These results suggest that previous lung diseases influence lung cancer risk independently of tobacco use and that these diseases are important for assessing individual risk.