Informace o publikaci
The role of Vδ2-negative γδ T cells during cytomegalovirus reactivation in recipients of allogeneic stem cell transplantation
| Autoři | |
|---|---|
| Rok publikování | 2010 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Blood |
| Fakulta / Pracoviště MU | |
| Citace | |
| Doi | http://dx.doi.org/10.1182/blood-2010-01-255166 |
| Klíčová slova | Receptor Repertoire; Peripheral blood; Infected Persons; Immune-Responses; NKG2d Receptor; CMV Disease; Bone marrow; B-Cells; Lymphocytes; V-Delta-1 |
| Přiložené soubory | |
| Popis | Reactivation of cytomegalovirus (CMV) remains a serious complication after allogeneic stem cell transplantation, but the role of gamma-delta T cells is undefined. We have studied the immune reconstitution of Vdelta2negative (Vdelta2neg) gamma-delta T cells, including Vdelta1 and Vdelta3 subsets and Vdelta2positive (Vdelta2pos) gamma-delta T cells in 40 patients during the first 24 months after stem cell transplantation. Our study shows new evidence for role of gamma-delta T cells in the immune response to CMV reactivation in transplantation recipients. |