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The PER3 VNTR polymorphism is a predictor of dietary composition in the Central European population

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BIENERTOVÁ VAŠKŮ Julie NOVÁK Jan ZLÁMAL Filip LIPKOVÁ Jolana ŠŤASTNÝ Jiří FOREJT Martin JACKOWSKÁ Aneta VAŠKŮ Anna

Rok publikování 2014
Druh Článek v odborném periodiku
Časopis / Zdroj Biological Rhythm Research
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1080/09291016.2014.913949
Obor Fyziologie
Klíčová slova PER3; VNTR polymorphism; dietary composition; sleep
Přiložené soubory
Popis Objectives, design: The aim of this case control study was to investigate possible associations of the variable number tandem-repeat (VNTR) polymorphism in the PER3 gene with obesity-related anthropometric traits, sleep and nutritional behaviour. Setting: A total of 329 volunteers of the Czech Caucasian origin were enrolled in the study. The allele-specific PCR-based method was used to determine the VNTR PER3 genotypes, dietary composition and time patterns were evaluated using seven day native food records and seven day sleep records. Results: No differences were observed in allele frequencies between the obese and the non-obese individuals. The PER3 VNTR polymorphism was associated with the total daily energy derived from carbohydrates (p < 0.01) and fat (p < 0.02). No association with sleep homeostasis was observed. Conclusions: We have demonstrated the relationship between the PER3 VNTR polymorphism and behavioural patterns of the food intake in the Central-European population.