Informace o publikaci

Telomere dynamics in adult hematological malignancies

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OLBERTOVÁ Helena PLEVOVÁ Karla STRÁNSKÁ Kamila POSPÍŠILOVÁ Šárka

Rok publikování 2019
Druh Článek v odborném periodiku
Časopis / Zdroj Biomedical Papers
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://biomed.papers.upol.cz/pdfs/bio/2019/01/01.pdf
Doi http://dx.doi.org/10.5507/bp.2018.084
Klíčová slova telomere; telomerase; leukemia; lymphoma; hematooncology; aging
Popis Telomeres are repetitive DNA sequences protecting physical ends of linear chromosomes against degradation and endto- end chromosomal fusion. Telomeres shorten with each cell division, which regulates the cellular lifespan in somatic cells and limits their renewal capacity. Cancer cells are often able to overcome this physiological barrier and become immortal with unlimited replicative capacity. In this review, we present current knowledge on the role of telomeres in human aging with a focus on their behavior in hematological malignancies of adults. Associations of telomere length to age-related diseases and to the prevention of telomere shortening are also discussed.
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