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Multifunctional Nano and Collagen-Based Therapeutic Materials for Skin Repair

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LAZURKO C KHATOON Z GOEL K SEDLÁKOVÁ Veronika CIMENCI CE AHUMADA M ZHANG L MAH TF FRANCO W SUURONEN EJ ALARCON EI

Rok publikování 2020
Druh Článek v odborném periodiku
Časopis / Zdroj ACS BIOMATERIALS SCIENCE & ENGINEERING
Citace
Doi http://dx.doi.org/10.1021/acsbiomaterials.9b01281
Klíčová slova wound healing; microskin columns; antiinfective nanomaterials; tissue regeneration
Popis A novel strategy is needed for treating nonhealing wounds, which is able to simultaneously eradicate pathogenic bacteria and promote tissue regeneration. This would improve patient outcome and reduce the number of lower limb amputations. In this work, we present a multifunctional therapeutic approach able to control bacterial infections, provide a protective barrier to a full-thickness wound, and improve wound healing in a clinically relevant animal model. Our approach uses a nanoengineered antimicrobial nanoparticle for creating a sprayable layer onto the wound bed that prevents bacterial proliferation and also eradicates preformed biofilms. As a protective barrier for the wound, we developed a thermoresponsive collagen-based matrix that has prohealing properties and is able to fill wounds independent of their geometries. Our results indicate that using a combination of the matrix with full-thickness microscopic skin tissue columns synergistically contributed to faster and superior skin regeneration in a nonhealing wound model in diabetic mice.

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