Chromosome location, genomic organization of the porcine COL10A1 gene and model structure of the NC1 domain.

Autoři MADSEN L — PETERSEN A — NIELSEN V — NISSEN P — DUNO Morten — KREJČÍ Lumír — BENDIXEN Christian — THOMSEN Bo
Druh Článek v odborném periodiku
Citace MADSEN, L, A PETERSEN, V NIELSEN, P NISSEN, Morten DUNO, Lumír KREJČÍ, Christian BENDIXEN a Bo THOMSEN. Chromosome location, genomic organization of the porcine COL10A1 gene and model structure of the NC1 domain. Cytogenet Genome Res., Basel, 2003, roč. 102, 1-4, s. 173-8. ISSN 1424-8581.
Originální jazyk angličtina
Obor Genetika a molekulární biologie
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Klíčová slova

The porcine COL10A1 gene, encoding the alpha1(X) chain of type X collagen, has been sequenced. The gene structure is evolutionarily conserved, consisting of three exons and two introns spanning 7100 bp. Linkage mapping localized the gene to chromosome 1, which is in agreement with human-pig homology maps. Furthermore, protein structure comparison of the functionally important carboxyl domain between species revealed that amino acid changes were few and mainly situated in loop regions.

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