Informace o publikaci

Alternation of retinoic acid induced neural differentiation of P19 embryonal carcinoma cells by reduction of reactive oxygen species intracellular production

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KONOPKA Roman KUBALA Lukáš LOJEK Antonín PACHERNÍK Jiří

Rok publikování 2008
Druh Článek v odborném periodiku
Časopis / Zdroj NEUROENDOCRINOLOGY LETTERS
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www http://www.ncbi.nlm.nih.gov/pubmed/18987612?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Obor Fyziologie
Klíčová slova embryonal carcinoma cells; neural differentiation; redox status; antioxidants
Popis Intracellularly generated reactive oxygen species (ROS) are thought to modulate redox sensitive signaling pathways and thus regulate cell physiology including proliferation and differentiation. However, the role of ROS in neuronal differentiation of embryonic pluripotent cells is unknown. For this reason, the modification of retinoic acid (RA) induced neuronal differentiation of mouse embryonal carcinoma cells P19 by selected ROS scavengers and flavoprotein inhibitor was evaluated.
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