Alternation of retinoic acid induced neural differentiation of P19 embryonal carcinoma cells by reduction of reactive oxygen species intracellular production

• Autoři: KONOPKA Roman; KUBALA Lukáš; LOJEK Antonín; PACHERNÍK Jiří
• Rok publikování: 2008
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: NEUROENDOCRINOLOGY LETTERS
• Fakulta / Pracoviště MU: Přírodovědecká fakulta
• www: http://www.ncbi.nlm.nih.gov/pubmed/18987612?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
• Obor: Fyziologie
• Klíčová slova: embryonal carcinoma cells; neural differentiation; redox status; antioxidants
• Popis: Intracellularly generated reactive oxygen species (ROS) are thought to modulate redox sensitive signaling pathways and thus regulate cell physiology including proliferation and differentiation. However, the role of ROS in neuronal differentiation of embryonic pluripotent cells is unknown. For this reason, the modification of retinoic acid (RA) induced neuronal differentiation of mouse embryonal carcinoma cells P19 by selected ROS scavengers and flavoprotein inhibitor was evaluated.

Související projekty

• Mechanismy řídící neurální diferenciaci myších embryonálních kmenových buněk in vitro