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Trombotická trombocytopenická purpura (TTP) u pacientky s roztroušenou sklerózou - kasuistika

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PRAKSOVÁ Petra ŠTOURAČ Pavel BEDNAŘÍK Josef

Druh Článek v odborném periodiku
Časopis / Zdroj Česká a slovenská neurologie a neurochirurgie
Fakulta / Pracoviště MU

Lékařská fakulta Institut biostatistiky a analýz

Citace
Obor Neurologie, neurochirurgie, neurovědy
Klíčová slova sclerosis multiplex; thrombocytopenia; microangiopathic hemolytic anemia; metaloproteinasis ADAMTS13; thrombotic thrombocytopenic purpura
Popis The authors report a case of 37-year old woman with multiple sclerosis who developed severe thrombocytopenia, anemia, renal insufficiency and neurological symptoms. The disease was classified as an attack of thrombotic thrombocytopenic purpura (TTP), Interferon beta and azathioprine therapy was discontinued due to possible association with the development of TTP. The patient was treated with corticosteroids, with a good therapeutic result. After 10 months, the attack of thrombotic thrombocytopenic purpura recurred. The article describes the principal clinical symptoms of this rare, but serious disorder.

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