Informace o publikaci
MiR-34b is associated with clinical outcome in triple-negative breast cancer patients.
| Autoři | |
|---|---|
| Rok publikování | 2012 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Diagnostic Pathology |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349474/?tool=pubmed |
| Doi | http://dx.doi.org/10.1186/1746-1596-7-31 |
| Obor | Onkologie a hematologie |
| Klíčová slova | triple-negative breast cancer; miR-34a; miR-34b; miR-34c; prognosis |
| Popis | Breast cancer is the most common malignancy with the highest incidence rates among women worldwide. Triple-negative breast cancer (TNBC) represents the major phenotype of basal-like molecular subtype of breast cancer, characterized by higher incidence in young women and a very poor prognosis. MicroRNAs (miRNAs) are small non-coding RNAs playing significant role in the pathogenesis of many cancers including breast cancer. Therefore, miRNAs are also potential prognostic and/or predictive biomarkers in triple-negative breast cancer patients. |