Informace o publikaci

Two-year results after convective radiofrequency water vapor thermal therapy of symptomatic benign prostatic hyperplasia


DIXON Christopher M. CEDANO Edwin Rijo PACÍK Dalibor VÍT Vítězslav VARGA Gabriel WAGRELL Lennart LARSON Thayne R. MYNDERSE Lance A.

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj Research and Reports in Urology
Fakulta / Pracoviště MU

Lékařská fakulta

Obor Ostatní obory vnitřního lékařství
Klíčová slova benign prostatic hyperplasia; lower urinary tract symptoms; convective RF; water vapor thermal therapy; minimally invasive
Popis Objective: The objective of this study was to assess the effectiveness and safety of convective radiofrequency (RF) water vapor thermal therapy in men with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH); a pilot study design with 2-year follow-up evaluations. Patients and methods: Men aged >=45 years with an International Prostate Symptom Score >=13, a maximum urinary flow rate (Qmax) <=15 mL/s, and prostate volume 20–120 cc were enrolled in a prospective, open-label pilot study using convective RF water vapor energy with the Rezum System. Patients were followed up for 2 years after transurethral thermal treatment at 3 international centers in the Dominican Republic, Czech Republic, and Sweden. The transurethral thermal therapy utilizes radiofrequency to generate wet thermal energy in the form of water vapor injected through a rigid endoscope into the lateral lobes and median lobe as needed. Urinary symptom relief, urinary flow, quality of life (QOL) impact, sexual function, and adverseevents (AEs) were assessed at 1 week, 1, 3, 6, 12, and 24 months. Results: LUTS, flow rate, and QOL showed significant improvements from baseline; prostate volumes were appreciably reduced. Sexual function was maintained and no de novo erectile dysfunction occurred. The responses evident as early as 1 month after treatment remained consistent and durable over the 24 months of study. Early AEs were typically transient and mild to moderate; most were related to endoscopic instrumentation. No procedure related to late AEs were seen. Conclusion: The Rezum System convective RF thermal therapy is a minimally invasive treatment for BPH/LUTS which can be performed in the office or as an outpatient procedure with minimal associated perioperative AEs. It has no discernable effect on sexual function and provides significant improvement of LUTS that remain durable at 2 years.

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