Informace o publikaci

Monophasic synovial sarcoma of the lower extremity at 20 weeks of pregnancy: a case report and review of the literature

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BIELIKOVA P. PILKA R. HUML K. MELICHAR B. SVEBISOVA H. JANKOVA J. PRASIL V. ZAMBO I. JANÍČEK Pavel

Rok publikování 2019
Druh Článek v odborném periodiku
Časopis / Zdroj CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://dx.doi.org/10.12891/ceog4877.2019
Doi http://dx.doi.org/10.12891/ceog4877.2019
Klíčová slova Synovial sarcoma; Malignancy; Pregnancy; Limb-sparing surgery
Popis Introduction: The incidence of malignancy in pregnancy is reported to range approximately between 0.02% and 1%. Synovial sarcoma (SS) is a rare aggressive mesenchymal tumor for which there are no treatment guidelines during pregnancy. Case Report: The authors report a 23-year-old primigravida presenting. at 20+0 weeks of pregnancy. with a growing painful mass in the left thigh. The diagnosis of monophasic SS grade 3 was confirmed by the presence of SYT gene fusion. On MRI scan there was a heterogeneous localized mass of size 75 x115 x103 mm, but there was no evidence of distant metastases. Limb-sparing surgery with clear-surgical margins was performed at 26+3 weeks of pregnancy. Adjuvant chemotherapy with two cycles of doxorubicin was followed by delivery of normal child by caesarean section at 36+3 weeks of pregnancy. Adjuvant radiotherapy of total dose of 66 Gray to the site of the resection had been administered followed by two cycles of doxorubicin. Conclusion: The patient is free of recurrence six months after the completion of the treatment.

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