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Paediatric Strategy Forum for medicinal product development of chimeric antigen receptor T-cells in children and adolescents with cancer ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration

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PEARSON Andrew D J ROSSIG Claudia MACKALL Crystal SHAH Nirali N BARUCHEL Andre REAMAN Gregory RICAFORT Rosanna HEENEN Delphine BASSAN Abraham BERNTGEN Michael BIRD Nick BLEICKARDT Eric BOUCHKOUJ Najat BROSS Peter BROWNSTEIN Carrie COHEN Sarah Beaussant TERESA de Rojas EHRLICH Lori FOX Elizabeth GOTTSCHALK Stephen HANSSENS Linda HAWKINS Douglas S HORAK Ivan D TAYLOR Danielle H JOHNSON Courtney KARRES Dominik LIGAS Franca LUDWINSKI Donna MAMONKIN Maksim MARSHALL Lynley MASOULEH Behzad K MATLOUB Yousif MAUDE Shannon MCDONOUGH Joe MINARD-COLIN Veronique NORGA Koen NYSOM Karsten PAPPO Alberto PEARCE Laura PIETERS Rob PULE Martin QUINTAS-CARDAMA Alfonso RICHARDSON Nick SCHUESSLER-LENZ Martina SCOBIE Nicole SERSCH Martina A SMITH Malcolm A ŠTĚRBA Jaroslav TASIAN Sarah K WEIGEL Brenda WEINER Susan L ZWAAN Christian Michel LESA Giovanni VASSAL Gilles

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj European Journal of Cancer
Fakulta / Pracoviště MU

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Citace
www https://www.sciencedirect.com/science/article/pii/S0959804921011709?via%3Dihub
Doi http://dx.doi.org/10.1016/j.ejca.2021.10.016
Klíčová slova Paediatric oncology; CAR T-cell; Adoptive cellular immunotherapy; Paediatric Strategy Forum; Drug development; Cancer therapeutics
Popis The seventh multi-stakeholder Paediatric Strategy Forum focused on chimeric antigen receptor (CAR) T-cells for children and adolescents with cancer. The development of CAR T-cells for patients with haematological malignancies, especially B-cell precursor acute lymphoblastic leukaemia (BCP-ALL), has been spectacular. However, currently, there are scientific, clinical and logistical challenges for use of CAR T-cells in BCP-ALL and other paediatric malignancies, particularly in acute myeloid leukaemia (AML), lymphomas and solid tumours. The aims of the Forum were to summarise the current landscape of CAR T-cell therapy development in paediatrics, too identify current challenges and future directions, with consideration of other immune effector modalities and ascertain the best strategies to accelerate their development and availability to children.

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