Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases

Základní údaje

Originální název Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases
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Další údaje

Citace SALZMAN, Richard, Kateřina KAŇKOVÁ, Lukáš PÁCAL, Josef TOMANDL, Kateřina ŠÍROVÁ a Rom KOSTŘICA. Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases. Neoplasma, Blarislava, Slovakia: Slovak Academy of Sciences, 2007, roč. 54, č. 4, s. 321-325. ISSN 0028-2685.
Originální název angličtina
Obor ORL, oftalmologie, stomatologie
Druh Článek v odborném periodiku
Klíčová slova antioxidative enzymes; head and neck cancer; metastasis; oxidative stress; polymorphism; syuperoxide dismutase

Anotace

Our results suggest that increased p-SOD at the time of the initial treatment for HNSCC is connected with a greater extent and nodal metastatic spread of the initial disease and an earlier disease relapse. Progression of diseases might be further modified by the presence of Ala/Ala genotype of the SOD2. Activity of p-SOD could thus offer diagnostic as well as prognostic value.

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