Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases

Autoři SALZMAN Richard — KAŇKOVÁ Kateřina PÁCAL Lukáš TOMANDL Josef — ŠÍROVÁ Kateřina — KOSTŘICA Rom
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Citace SALZMAN, Richard, Kateřina KAŇKOVÁ, Lukáš PÁCAL, Josef TOMANDL, Kateřina ŠÍROVÁ a Rom KOSTŘICA. Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases. Neoplasma, Blarislava, Slovakia: Slovak Academy of Sciences, 2007, roč. 54, č. 4, s. 321-325. ISSN 0028-2685.
Originální jazyk angličtina
Obor ORL, oftalmologie, stomatologie
Klíčová slova antioxidative enzymes; head and neck cancer; metastasis; oxidative stress; polymorphism; syuperoxide dismutase

Our results suggest that increased p-SOD at the time of the initial treatment for HNSCC is connected with a greater extent and nodal metastatic spread of the initial disease and an earlier disease relapse. Progression of diseases might be further modified by the presence of Ala/Ala genotype of the SOD2. Activity of p-SOD could thus offer diagnostic as well as prognostic value.

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