Colorectal cancer is among the most common malignancies worldwide, and its high biological variability makes effective treatment challenging. This project aims to introduce a promising 3D in vitro model patient-derived tumoroids, that overcomes the limitations of traditional 2D cell cultures and patient-derived xenografts (PDXs) in mice. Tumoroids provide highly sensitive and physiologically relevant platforms for studying tumor biology and represent a significant step toward personalized medicine.
Furthermore, the project will investigate the effects of newly synthesized conjugates of schizophyllan with the chemotherapeutic agent, oxaliplatin, on colorectal cancer tumoroids. The obtained results will be compared with responses observed in PDX models to assess whether tumoroids can serve as reliable alternatives to animal experiments. This approach aligns with the 3Rs principles (Replacement, Reduction and Refinement) and contributes to the development of more ethical and predictive cancer research methodologies.

Cíle udržitelného rozvoje

Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.