The Ecm11-Gmc2 Complex Promotes Synaptonemal Complex Formation through Assembly of Transverse Filaments in Budding Yeast

• Autoři: HUMPHRYES Neil; LEUNG Wing-Kit; ARGUNHAN Bilge; TERENTYEV Yaroslav; DVOŘÁČKOVÁ Martina; TSUBOUCHI Hideo
• Rok publikování: 2013
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: PLOS Genetic
• Fakulta / Pracoviště MU: Středoevropský technologický institut
• Doi: http://dx.doi.org/10.1371/journal.pgen.1003194
• Obor: Genetika a molekulární biologie
• Klíčová slova: MEIOTIC CHROMOSOME SYNAPSIS; MEIOSIS-SPECIFIC PROTEIN; DOUBLE-STRAND BREAK; SACCHAROMYCES-CEREVISIAE; ELEMENT PROTEIN; RECOMBINATION; SUMO; SEGREGATION; INITIATION; RED1
• Popis: Homologous chromosome pairing is one of the crutial step in meiotic division of gametes. Zip1 protein represents a key component during the formation of so-called synaptonemal complex (SC). Analysis of two Zip-related proteins from budding yeast S.cerevisiae revealed that Ecm11 and Gmc2 together with SUMO participate in reguation and correct function of Zip1 during SC assembly.

Související projekty

• CEITEC - středoevropský technologický institut