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Association of the ACE rs4646994 and rs4341 Polymorphisms with the Progression of Carotid Atherosclerosis in Slovenian Patients with Type 2 Diabetes Mellitus

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MERLO S. NOVÁK Jan TKÁČOVÁ Nikola STARČEVIĆ Nikolajević J. LETONJA Šantl M. MAKUC J. VUJKOVAC Cokan A. LETONJA J. BREGAR D. ZORC M. ROJKO M. MANKOČ S. KRUŽLIAK Peter PETROVIČ D.

Rok publikování 2015
Druh Článek v odborném periodiku
Časopis / Zdroj Balkan Journal of Medical Genetics
Fakulta / Pracoviště MU

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Citace
Doi http://dx.doi.org/10.1515/bjmg-2015-0084
Obor Fyziologie
Klíčová slova Angiotensin-converting-enzyme (ACE) gene polymorphism; Association study; Carotid atherosclerosis; Type 2 diabetes mellitus (T2DM)
Popis The current study was designed to reveal possible associations between the angiotensin-converting-enzyme (ACE) gene polymorphisms (rs4646994 and rs4341) with markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM) in a 4-year-long follow-up study. Five hundred and ninety-five T2DM subjects and 200 control subjects were enrolled. Genotyping of ACE polymorphisms was performed using KASPar assays, and ultrasound examinations were performed twice (at the enrollment and at follow-up). With regard to the progression of atherosclerosis in subjects with T2DM, statistically significant differences were demonstrated in the change of the sum of carotid plaques thickness for the rs4646994 polymorphism. We did not demonstrate an association between the tested polymorphisms (rs4646994 and rs4341) and either carotid intima media thickness (CIMT) or CIMT progression in a 3.8-year period. In our study, we demonstrated that subjects with T2DM with the DD genotype of the rs4646994 [ACE insertion/deletion (I/D)] polymorphism had faster progression of atherosclerosis in comparison to subjects with other genotypes.

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