Informace o publikaci

Nuclear hormone receptors: Ancient 9aaTAD and evolutionally gained NCoA activation pathways

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PISKÁČEK Martin HAVELKA Marek JENDRUCHOVÁ Kristína KNIGHT Andrea

Rok publikování 2019
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of steroid biochemistry and molecular biology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://dx.doi.org/10.1016/j.jsbmb.2018.11.008
Doi http://dx.doi.org/10.1016/j.jsbmb.2018.11.008
Klíčová slova 9aaTAD; CBP; HNF4; KIX; MED15; PPAR; RARa; VDL
Popis In higher metazoans, the nuclear hormone receptors activate transcription trough their specific adaptors, nuclear hormone receptor adaptors NCoA, which are absent in lower metazoans. The Nine amino acid TransActivation Domain, 9aaTAD, was reported for a large number of the transcription activators that recruit general mediators of transcription. In this study, we demonstrated that the 9aaTAD from NHR-49 receptor of nematode C.elegans activates transcription as a small peptide. We showed that the ancient 9aaTAD domains are conserved in the nuclear hormone receptors including human HNF4, RARa, VDR and PPARg. Also their small 9aaTAD peptides effectively activated transcription in absence of the NCoA adaptors. We also showed that adjacent H11 domains in ancient and modern hormone receptors have an inhibitory effect on their 9aaTAD function.
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