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Assessment of exhaled breath condensate for non-invasive diagnosis of gastroesophageal reflux disease

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KONEČNÝ Štefan DOLINA Jiří DOUBKOVÁ Martina SKŘIČKOVÁ Jana KINDLOVÁ Dagmar POKOJOVÁ Eva ĎURČ Pavol LAČNÁ Júlia GREGUŠ Michal FORET František KUBÁŇ Petr

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Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Popis Introduction: Gastroesophageal reflux disease (GERD) is a disease caused by backflow of gastric contents into the esophagus due to the failure of physiological antireflux mechanisms and can lead to esophageal and extraesophageal symptomatology. Extraesophageal reflux (EER) is a condition where refluxate penetrate above the upper esophageal sphincter in to the oral cavity, pharynx, upper and lower respiratory tract and leads to pathological changes. Monitoring of various parameters in exhaled breath condensate (EBC) in patients suffering from extraesophageal symptoms of GERD is non-invasive and simple approach to assess the gastroesophageal reflux. The aim was to compare the pH and total ionic profile of EBC with 24-hour multichannel intraluminal impedance and pH monitoring (MII-pH) and Peptest in a group of patients with acid reflux (pH<4), weakly acid reflux (pH 4-7) and healthy controls
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