Escape of Tick-Borne Flavivirus from 2′-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness

• Autoři: EYER Luděk; KONDO Hirofumi; ZOUHAROVÁ Darina; HIRANO Minato; VALDÉS James J.; MUTO Memi; KASTL Tomáš; KOBAYASHI Shintaro; HAVIERNIK Jan; IGARASHI Manabu; KARIWA Hiroaki Kariwa; VACULOVIČOVÁ Markéta; ČERNÝ Jiří; KIZEK René; KRÖGER Andrea; LIENENKLAUS Stefan; DEJMEK Milan; NENCKA Radim; PALUS Martin; SALÁT Jiří; DE CLERCQ Erik; YOSHII Kentaro; RŮŽEK Daniel
• Rok publikování: 2017
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: JOURNAL OF VIROLOGY
• www: https://jvi.asm.org/content/91/21/e01028-17
• Doi: http://dx.doi.org/10.1128/JVI.01028-17
• Klíčová slova: antiviral agentsantiviral therapyescape mutanttick-borne encephalitis virustick-borne pathogens