Informace o publikaci

Diagnostic relevance of 18F-FDG PET/CT in newly diagnosed patients with monoclonal gammopathy of undetermined significance (MGUS): Single-center experience

Autoři

SANDECKÁ Viera ADAM Zdeněk KREJČÍ Marta ŠTORK Martin ŘEHÁK Zdeněk KOUKALOVÁ Renata ŠEVČÍKOVÁ Sabina BROŽOVÁ Lucie KRÁL Zdeněk MAYER Jiří POUR Luděk

Rok publikování 2020
Druh Článek v odborném periodiku
Časopis / Zdroj Neoplasma
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=6768&category_id=160&option=com_virtuemart&vmcchk=1&Itemid=1
Doi http://dx.doi.org/10.4149/neo_2020_191104N1137
Klíčová slova monoclonal gammopathy; cancer; multiple myeloma; PET/CT
Popis Monoclonal gammopathy of undetermined significance (MGUS) is a known precursor of more serious cancers, such as multiple myeloma (MM), Waldenstrom macroglobulinemia (MW) and other lymphoproliferative disorders. Using 18F-FDG PET/CT, we aimed to evaluate its benefit in early detection of various accompanying disorders and illnesses in MGUS patients. We prospectively analyzed the diagnostic relevance of 18F-FDG PET/CT in 390 newly diagnosed MGUS patients. On 18F-FDG PET/CT scans, the presence of focal or diffuse areas of detectable increased tracer uptake was recorded in 37 (9.5%) MGUS patients. The most frequent pathology was lymphadenopathy (3.8%), followed by thyroid diseases (2.1%), rheumatic diseases (1.8%), and other solid malignancies (1.5%). These results have major implications for confirmed associations of MGUS with numerous malignant and non-malignant disorders. We believe that 18F-FDG PET/CT imaging in newly diagnosed MGUS patients may be useful in early detection of other serious pathologies, not only in predicting progression of MGUS to active MM, and should be strongly recommended if available.