Informace o publikaci

Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope (R)-Global Registry for Emerging Fungal Infections

Autoři	SALMANTON-GARCIA Jon KOEHLER Philipp KINDO Anupma FALCES-ROMERO Iker GARCIA-RODRIGUEZ Julio RÁČIL Zdeněk CHEN Sharon C. A. KLIMKO Nikolai DESOUBEAUX Guillaume THOMPSON George R. BENITEZ-PENUELA Miguel-Angel RODRIGUEZ Jose-Yesid SHEPPARD Donald C. HOENIGL Martin LE GOVIC Yohann BADALI Hamid BADDLEY John W. CHANDER Jagdish INGRAM Paul R. PAKSTIS Diana L. MELLINGHOFF Sibylle C. ATICI Serkan CESARO Simone CHAKRABARTI Arunaloke DUPONT Damien GONZALEZ Gloria M. HATVANI Lorant HERBRECHT Raoul KLYASOVA Galina LASS-FLORL Cornelia MARES Mihai MULLANE Kathleen VINH Donald C. WISPLINGHOFF Hilmar LACKNER Michaela CORNELY Oliver A. SEIDEL Danila
Rok publikování	2020
Druh	Článek v odborném periodiku
Časopis / Zdroj	The Journal of infection
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://www.journalofinfection.com/article/S0163-4453(20)30549-1/fulltext
Doi	http://dx.doi.org/10.1016/j.jinf.2020.08.015
Klíčová slova	Rare; Invasive fungal infections; Registry; Mold; Yeast
Popis	Objectives: Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, little is known about extremely rare IFI. Methods: Extremely rare IFI collected in the FungiScope (R) registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales. Results: Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScope (R). Dematiaceae (35.5%), Hypocreales (23.1%), Mucorales (11.8%), and Saccharomycetales (11.3%) caused most IFI. Most patients had an underlying malignancy (38.7%) with acute leukemia accounting for 50% of cancers. Dissemination was observed in 26.9% of the patients. Complete or partial clinical response rate was 68.3%, being highest in Eurotiales (82.4%) and in Agaricales (80.0%). Overall mortality rate was 29.3%, ranging from 11.8% in Eurotiales to 50.0% in Mucorales. Conclusions: Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens. (C) 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.