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Web-based tools for computational enzyme design

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MARQUES Sérgio Manuel PLANAS IGLESIAS Joan DAMBORSKÝ Jiří

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Current Opinion in Structural Biology
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://www.sciencedirect.com/science/article/pii/S0959440X21000233?via%3Dihub
Doi http://dx.doi.org/10.1016/j.sbi.2021.01.010
Klíčová slova PROTEIN; STABILITY; DYNAMICS; VIEW
Přiložené soubory
Popis Enzymes are in high demand for very diverse biotechnological applications. However, natural biocatalysts often need to be engineered for fine-tuning their properties towards the end applications, such as the activity, selectivity, stability to temperature or co-solvents, and solubility. Computational methods are increasingly used in this task, providing predictions that narrow down the space of possible mutations significantly and can enormously reduce the experimental burden. Many computational tools are available as web-based platforms, making them accessible to non-expert users. These platforms are typically user-friendly, contain walk-throughs, and do not require deep expertise and installations. Here we describe some of the most recent outstanding web-tools for enzyme engineering and formulate future perspectives in this field.
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