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Nanoparticles as tags for protein tissue analysis using laser ablation inductively coupled plasma and mass spectrometry

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KUCHYNKA Michaela MASAŘÍK Michal VLČNOVSKÁ Marcela KANICKÝ Viktor VACULOVIČ Tomáš

Rok publikování 2019
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Popis Laser ablation with inductively coupled plasma is still more used in life science as biology and biomedicine and the utilization of metals and proteins determination simultaneously is also growing up. We have developed a new strategy of antibody labeling by nanoparticles which are composed of thousands of atoms and thus increase the sensitivity enormously and decrease the limit of detection (tens of picograms). The ability of simultaneous imaging proteins such as p53 and elements and their distribution in biological tissue (especially tumour) is presented in this work.
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