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Novel antimicrobial genetic elements in methicillin-resistant Macrococcus armenti

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Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj Microbial Drug Resistance
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Klíčová slova antibiotic resistance; Staphylococcaceae; whole genomic sequence; methicillin resistance; mecD; MLS
Přiložené soubory
Popis Macrococcus armenti has been described as a new bacterial species colonizing nasal cavities and skin of calves and pigs in 2022.1 Following this description, two Macrococcus sp. strains sharing the same SmaI pulsotype (CCM 2607= B-P 25 and CCM 2609 =B-P 26) isolated from pig-derived samples (origin not specified, but either skin of pigs or bacon) in 1963 and deposited in the Czech Collection of Microorganisms (CCM) were also classified as M. armenti.2 While the recent strains isolated in 2017, 2019 and 2021 harbored the methicillin resistance gene mecD,1 this gene was not detected by PCR in the older strains from the early sixties prompting us to determine antimicrobial susceptibility testing and perform a comparative genomic analysis of the different elements containing antibiotic resistance genes in M. armenti. This comparative genomic analysis of decades-old and more recent isolates showed that M. armenti acquired antibiotic resistance genes through the integration of genetic elements similar to those found in other Macrococcus and Mammaliicoccus, as well as in Enterococcus and Streptococcus. It also highlighted that additional antibiotic resistance genes such as ant(6)-Ia can insert into McRImecD. The presence of different types of genetic elements in M. armenti underlines once again the propensity of Macrococcus to evolve and adapt its genetic material to survive antimicrobial selective pressure as it is commonly exerted in animal husbandry.
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