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Linear IgA Bullous Dermatosis

Název česky Lineární IgA bulózní dermatóza
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MARVANOVÁ Edita BŘEZINOVÁ Eva JEDLIČKOVÁ Hana BEDNAŘÍK Zdeněk

Rok publikování 2022
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Popis Linear IgA bullous dermatosis (LABD) is a rare acquired autoimmune blistering disease that affects both children and adults. It may be idiopathic or induced by multiple drugs. The case report describes a 26-year-old woman who developed an abrupt onset of severe generalized vesicular rash, with intense pruritus, predominantly on the trunk. Skin biopsy showed subepidermal blister formation and direct immunofluorescence revealed the linear IgA antibodies deposition at the dermo-epidermal junction. To induce the remission the patient was treated with systemic and topical corticosteroids together with antibiotics. The mainstay of treatment of LABD is dapsone. Nowadays our patient’s disease is controlled by dapsone in combination with a low dose of oral corticosteroids. The disease may run a several years course and then remit.

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