Informace o publikaci

Definitions and treatment of oligometastatic oesophagogastric cancer according to multidisciplinary tumour boards in Europe

Autoři

KROESE Tiuri E VAN HILLEGERSBERG Richard SCHOPPMANN Sebastian DESEYNE Pieter R A J NAFTEUX Philippe OBERMANNOVÁ Radka NORDSMARK Marianne PFEIFFER Per HAWKINS Maria A SMYTH Elizabeth MARKAR Sheraz HANNA George B CHEONG Edward CHAUDRY Asif ELME Anneli ADENIS Antoine PIESSEN Guillaume GANI Cihan BRUNS Christiane J MOEHLER Markus LIAKAKOS Theodore REYNOLDS John MORGANTI Alessio ROSATI Riccardo CASTORO Carlo UGO Domenico ROVIELLO Franco BENCIVENGA Maria GIOVANNI de Manzoni JEENE Paul VAN SANDICK JOHANNA W. MUIJS Christel SLINGERLAND Marije NIEUWENHUIJZEN Grard WIJNHOVEN Bas BEEREPOOT Laurens V KOLODZIEJCZYK Piotr POLKOWSKI Wojciech P ALSINA Maria PERA Manuel KANONNIKOFF Tania F NILSSON Magnus GUCKENBERGER Matthias MONIG Stefan WAGNER Dorethea WYRWICZ Lucjan BERBEE Maaike GOCKEL Ines LORDICK Florian GRIFFITHS Ewen A VERHEIJ Marcel VAN ROSSUM PETER S. N. VAN LAARHOVEN HANNEKE WM W. M.

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj European Journal of Cancer
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.sciencedirect.com/science/article/pii/S0959804921012971?via%3Dihub
Doi http://dx.doi.org/10.1016/j.ejca.2021.11.032
Klíčová slova Oesophageal neoplasm; Gastric neoplasm; Neoplasm metastasis; Metastasectomy; Radiosurgery; Oligometastasis
Popis Background: Consensus about the definition and treatment of oligometastatic oesophagogastric cancer is lacking. Objective: To assess the definition and treatment of oligometastatic oesophagogastric cancer across multidisciplinary tumour boards (MDTs) in Europe. Material and methods: European expert centers (n Z 49) were requested to discuss 15 real-life cases in their MDT with at least a medical, surgical, and radiation oncologist present. The cases varied in terms of location and number of metastases, histology, timing of detection (i.e. synchronous versus metachronous), primary tumour treatment status, and response to systemic therapy. The primary outcome was the agreement in the definition of oligometastatic disease at diagnosis and after systemic therapy. The secondary outcome was the agreement in treatment strategies. Treatment strategies for oligometastatic disease were categorised into up -front local treatment (i.e. metastasectomy or stereotactic radiotherapy), systemic therapy followed by restaging to consider local treatment or systemic therapy alone. The agreement across MDTs was scored to be either absent/poor (< 50%), fair (50%-75%), or consensus (>= 75%). Results: A total of 47 MDTs across 16 countries fully discussed the cases (96%). Oligometastatic disease was considered in patients with 1-2 metastases in either the liver, lung, retroperitoneal lymph nodes, adrenal gland, soft tissue or bone (consensus). At follow-up, oligometastatic disease was considered after a median of 18 weeks of systemic therapy when no progression or progression in size only of the oligometastatic lesion(s) was seen (consensus). If at restaging after a median of 18 weeks of systemic therapy the number of lesions progressed, this was not considered as oligometastatic disease (fair agreement). There was no consensus on treatment strategies for oligometastatic disease. Conclusion: A broad consensus on definitions of oligometastatic oesophagogastric cancer was found among MDTs of oesophagogastric cancer expert centres in Europe. However, high practice variability in treatment strategies exists.

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info