Informace o publikaci

Hypertension treatment in patients with sleep apnea from the European Sleep Apnea Database (ESADA) cohort - towards precision medicine

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SVEDMYR Sven HEDNER Jan BONSIGNORE Maria Rosaria LOMBARDI Carolina PARATI Gianfranco LUDKA Ondřej ZOU Ding GROTE Ludger

Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Sleep Research
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://onlinelibrary.wiley.com/doi/10.1111/jsr.13811
Doi http://dx.doi.org/10.1111/jsr.13811
Klíčová slova antihypertensive treatment; beta-blocker; blood pressure control; diuretic; hypertension; obstructive sleep apnea
Popis We recruited 5,970 patients with hypertension with obstructive sleep apnea (OSA) on current antihypertensive treatment from the European Sleep Apnea Database (ESADA) cohort. The group was subdivided into those receiving monotherapy (n = 3,594) and those receiving dual combined therapy (n = 2,376). We studied how major OSA confounders like age, gender, and body mass index as well as the degree of sleep apnea modified office systolic and diastolic blood pressure. Beta-blockers alone or in combination with a diuretic were compared with other antihypertensive drug classes. Monotherapy with beta-blocker was associated with lower systolic blood pressure, particularly in non-obese middle-aged males with hypertension. Conversely, the combination of a beta-blocker and a diuretic was associated with lower systolic and diastolic blood pressure in patients with hypertension with moderate-severe OSA. Systolic blood pressure was better controlled in female patients using this combined treatment. Our cross-sectional data suggest that specific clinical characteristics and type of antihypertensive medication influence the degree of blood pressure control in patients with hypertension with OSA. Controlled trials are warranted.

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