Informace o publikaci

New directions in the experimental therapy of tick-borne encephalitis.


EYER Luděk SELEY-RADTKE Katherine RŮŽEK Daniel

Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj Antiviral Research
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Klíčová slova Tick-borne encephalitis; Tick-borne encephalitis virus; Antivirals; Monoclonal antibodies; Immunotherapy
Popis Tick-borne encephalitis (TBE) is a potentially fatal disease common in much of Europe and Asia. There is no specific therapy for the treatment of TBE patients. However, several efforts are being made to develop small molecules that specifically interfere with the life cycle of TBE virus. In particular, recently various nucleoside analogues that can inhibit the viral replicase, such as the RNA-dependent RNA polymerase or viral methyltransferases, have been explored. In addition, human or chimeric (i.e., structural chimeras that combine mouse variable domains with human constant domains) monoclonal antibodies with promising potential for post-exposure prophylaxis or early therapy have been developed. This review summarizes the latest directions and experimental approaches that may be used to combat TBE in humans.

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info