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Sustainability of biologic treatment in paediatric patients with Crohn's disease: population-based registry analysis

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HRADSKY Ondrej COPOVA Ivana DURILOVA Marianna KAZEKA Denis LERCHOVA Tereza MITROVA Katarina SCHWARZ Jan VETROVCOVA Romana EL-LABABIDI Nabil KARASKOVA Eva VEGHOVA-VELGANOVA Maria SULAKOVA Astrid GONSORCIKOVA Lucie SOBOTKOVÁ Markéta ZENISKOVA Ivana ZIMEN Martin BORTLIK Martin BRONSKY Jiri

Rok publikování 2024
Druh Článek v odborném periodiku
Časopis / Zdroj Pediatric Research
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.nature.com/articles/s41390-023-02913-7
Doi http://dx.doi.org/10.1038/s41390-023-02913-7
Klíčová slova Crohn’s disease; biologic treatment; paediatric patients
Popis BackgroundWe aimed to evaluate the predictors of sustainability of biologic drugs for paediatric patients with Crohn's disease (CD).MethodsThe Czech National Prospective Registry of Biologic and Targeted Therapy of Inflammatory Bowel Disease (CREdIT) was used to identify the biologic treatment courses in paediatric patients with CD. Mixed-effects Cox models and propensity score analyses were employed to evaluate predictors of treatment sustainability.ResultsAmong the 558 observations of 473 patients, 264 were treated with adalimumab (47%), 240 with infliximab (43%), 41 with ustekinumab (7%), and 13 with vedolizumab (2%). Multivariable analysis revealed higher discontinuation risk with infliximab compared to adalimumab (HR = 0.600, 95%CI 0.389-0.926), both overall and in first-line treatment (HR = 0.302, 95%CI 0.103-0.890). Infliximab versus adalimumab was associated with shorter time to escalation (HR = 0.094, 95%CI 0.043-0.203). Propensity-score analysis demonstrated lower sustainability of infliximab (HR = 0.563, 95%CI 1.159-2.725). The time since diagnosis to treatment initiation (HR = 0.852, 95%CI 0.781-0.926) was the most important predictor. Baseline immunosuppressive therapy prolonged sustainability with infliximab (HR = 2.899, 95%CI 1.311-6.410).ConclusionsGiven the results suggesting shorter sustainability, the need for earlier intensification and thus higher drug exposure, and the greater need for immunosuppression with infliximab than with adalimumab, the choice of these drugs cannot be considered completely equitable.ImpactOur study identified predictors of sustainability of biologic treatment in paediatric patients with Crohn's disease, including adalimumab (versus infliximab), early initiation of biologic treatment, and normalised baseline haemoglobin levels. Infliximab treatment was associated with earlier intensification, higher drug exposure, and a greater need for immunosuppression.Parents and patients should be fully informed of the disadvantages of intravenous infliximab versus adalimumab during the decision-making process.This study emphasises the importance of not delaying the initiation of biologic therapy in paediatric patients with Crohn's disease.

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