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Metabolic profiling of silymarin constituents in urine and feces of healthy volunteers: A 90-day study

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LNENICKOVA Katerina VRBA Jiri KOSINA Pavel PAPOUSKOVA Barbora MEKADIM Chahrazed MRAZEK Jakub SOVA Milan SOVOVA Eliska VALENTOVA Katerina KREN Vladimir KOURILOVA Pavla VRBKOVA Jana ULRICHOVA Jitka

Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Functional Foods
Citace
Doi http://dx.doi.org/10.1016/j.jff.2022.105391
Klíčová slova Flavonolignans; Silybin; Taxifolin; Human metabolites; Mass spectrometry; Fecal microbiota
Popis This study examined the metabolism of flavonolignans and taxifolin in 33 healthy adult male volunteers, who received 200 mg of silymarin orally twice daily for three months. First-morning urine and feces collected on days 10 and 90 were analyzed by UHPLC-MS and bacterial composition of feces was investigated by Next Generation Sequencing. The analyses revealed 5/4 types of flavonolignan/taxifolin metabolites in urine and 13/10 types of metabolites in feces, with large differences in total metabolite levels in both urine and feces observed among individual participants. In urine, 21 and 23 participants showed some increase in the total amount of flavonolignan and taxifolin metabolites, respectively, on day 90 compared with day 10. In feces, some correlation was found between the amount of metabolites and the composition of the intestinal microbiota. In conclusion, silymarin flavonolignans and taxifolin undergo multiple biotransformation reactions, and the metabolic profiles of the constituents considerably vary among individuals.

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