Informace o publikaci

Relationship between parameters of cell-mediated immunity, oxidative stress and head and neck squamous cell carcinoma

Název česky Vztahy mezi parametry buněčné imunity, oxidačního stresu a karcinomu hlavy a krku
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TOMANDL Josef SALZMAN Richard HORÁKOVÁ Zuzana KOSTŘICA Rom

Rok publikování 2007
Druh Článek ve sborníku
Konference Book of abstracts from the conference Synthetic and natural compounds in cancer therapy and prevention.
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Biochemie
Klíčová slova head and neck cell carcinoma; oxidative stress; cell-mediated immunity
Popis Oxidative stress, alterations in host immunity and inflammation may contribute to genesis and progression of head and neck squamous cell carcinoma (HNSCC). We investigated relationships between malondialdehyde (MDA) as a marker of lipid peroxidation and parameters of activated macrophages, i.e. tumor necrosis factor alpha as a marker of inflammation and neopterin as a marker of cell-mediated immunity and clinical stage of HNSCC. Our results confirm the role of activated macrophages and the cellular immune system in HNSCC. In patients with activated T-lymphocytes, levels of TNF alpha inversely reflected the prognosis of disease. Although production of MDA in HNSCC patients is normal, it seems that activated T-lymphocytes contribute to lipid peroxidation.
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