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Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function

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JARKOVSKÝ Jiří PAŘENICA Jiří MIKLÍK Roman PÁVKOVÁ GOLDBERGOVÁ Monika KALA Petr MALÁSKOVÁ Lenka ČERMÁKOVÁ Zdeňka POLOCZEK Martin VYTISKA Miroslav KUBKOVÁ Lenka HELÁNOVÁ Kateřina PARENICOVA I. LITTNEROVÁ Simona DOSTALOVA L. KUBENA P. VAŠKŮ Anna ŠPINAR Jindřich

Druh Článek v odborném periodiku
Časopis / Zdroj EUROPEAN JOURNAL OF CARDIOVASCULAR MEDICINE
Fakulta / Pracoviště MU

Lékařská fakulta Přírodovědecká fakulta Fakulta sportovních studií Institut biostatistiky a analýz

Citace
Doi http://dx.doi.org/10.5083/ejcm.20424884.67
Obor Kardiovaskulární nemoci včetně kardiochirurgie
Klíčová slova aortic pulse pressure; natriuretic peptides; marker
Popis Wide aortic pulse pressure (PP) and levels of natriuretic peptides were repeatedly demonstrated as predictors of cardiovascular morbidity and mortality even in a population without a history of heart disease. The aim of the work was to find determinants of invasively measured aortic pulse pressure and B-type natriuretic peptide (BNP), and a relationship of both markers in stable patients undergoing diagnostic coronary angiography with preserved left ventricle systolic function. Population and methods: A total of 386 stable patients with left ventricle ejection fraction > 50%, without acute myocardial infarction, aortic or mitral valve disease were enrolled. Invasive intra-aortic blood pressure was measured using a fluid-filled catheter in the ascending aorta. Samples of venous blood for analysis of the BNP level were drawn before coronary angiography. Results: We found a positive correlation between aortic systolic blood pressure (SBP) and PP (Pearson’s correlation coefficient = 0.44, p<0.001). Positive relationships were determined among aortic PP and gender, age, BNP, glycaemia, high-density lipoprotein (HDL) cholesterol, hypertension and diabetes mellitus. Negative relationships were found among aortic PP and height, weight and ischemic heart disease, but only gender and age were detected as independent factors in multivariate model. Positive correlation of BNP with age, aortic PP, Left ventricular end diastolic pressure (LVEDP), hypertension, smoking and a negative correlation with creatinine, total cholesterol and ischemic heart disease were shown; only age, creatinine, cholesterol and non- smoker status were independent predictors of BNP value in multivariate model. Conclusion: We found independent determinants of two important predictive markers of cardio-vascular morbidity and mortality – BNP and PP - in group of stable patients.
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