With A4L_ACTIONS, we aim to use the established framework of Alliance4Life to improve the cultures and networks of health research-performing institutions in a major part of the EU-13: the Central and Eastern Europe (CEE). Our activities will support the implementation of good practice successfully piloted by Alliance4Life members in institutional, national, and international strategies and policies across the broad landscape of health R&I in CEE. Moreover, these initiatives are aligned with the overall EU governance efforts to create a real single market for research, education and innovation, bridging the performance gap between eastern and western Europe. We will also strive to untap the potential for innovation in CEE by revealing and promoting opportunities for intersectoral and interdisciplinary collaboration