Informace o publikaci

MicroRNA-Based Therapy in Animal Models of Selected Gastrointestinal Cancers

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MERHAUTOVÁ Jana DEMLOVÁ Regina SLABÝ Ondřej

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj Frontiers in Pharmacology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://journal.frontiersin.org/article/10.3389/fphar.2016.00329/full
Doi http://dx.doi.org/10.3389/fphar.2016.00329
Obor Farmakologie a lékárnická chemie
Klíčová slova microRNA; gastric cancer; pancreatic cancer; gallbladder cancer; colorectal cancer; animal model; mice; preclinical testing
Přiložené soubory
Popis Gastrointestinal cancer accounts for the 20 most frequent cancer diseases worldwide and there is a constant urge to bring new therapeutics with new mechanism of action into the clinical practice. Quantity of in vitro and in vivo evidences indicate, that exogenous change in pathologically imbalanced microRNAs (miRNAs) is capable of transforming the cancer cell phenotype. This review analyzed preclinical miRNA-based therapy attempts in animal models of gastric, pancreatic, gallbladder, and colorectal cancer. From more than 400 original articles, 26 was found to assess the effect of miRNA mimics, precursors, expression vectors, or inhibitors administered locally or systemically being an approach with relatively high translational potential. We have focused on mapping available information on animal model used (animal strain, cell line, xenograft method), pharmacological aspects (oligonucleotide chemistry, delivery system, posology, route of administration) and toxicology assessments. We also summarize findings in the field pharmacokinetics and toxicity of miRNA-based therapy.
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