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Advanced technologies towards improved HPV diagnostics

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BARTOŠÍK Martin MORÁŇOVÁ Ludmila IZADI Nasim STRMISKOVÁ Johana SEBUYOYA Ravery Jovinary HOLČÁKOVÁ Jitka HRSTKA Roman

Rok publikování 2024
Druh Článek v odborném periodiku
Časopis / Zdroj JOURNAL OF MEDICAL VIROLOGY
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www webová stránka časopisu
Doi http://dx.doi.org/10.1002/jmv.29409
Klíčová slova RISPR-Cas; human papillomavirus; isothermal amplification techniques; lab-on-a-chip; lateral flow assay; nanomaterials
Popis Persistent infection with high-risk types of human papillomaviruses (HPV) is a major cause of cervical cancer, and an important factor in other malignancies, for example, head and neck cancer. Despite recent progress in screening and vaccination, the incidence and mortality are still relatively high, especially in low-income countries. The mortality and financial burden associated with the treatment could be decreased if a simple, rapid, and inexpensive technology for HPV testing becomes available, targeting individuals for further monitoring with increased risk of developing cancer. Commercial HPV tests available in the market are often relatively expensive, time-consuming, and require sophisticated instrumentation, which limits their more widespread utilization. To address these challenges, novel technologies are being implemented also for HPV diagnostics that include for example, isothermal amplification techniques, lateral flow assays, CRISPR-Cas-based systems, as well as microfluidics, paperfluidics and lab-on-a-chip devices, ideal for point-of-care testing in decentralized settings. In this review, we first evaluate current commercial HPV tests, followed by a description of advanced technologies, explanation of their principles, critical evaluation of their strengths and weaknesses, and suggestions for their possible implementation into medical diagnostics.
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