Caffeic acid affects an induced differentiation process into granulocyte stage in HL-60 myeloid leukaemia cell line

• Autoři: VESELSKÁ Renata; ZITTERBART Karel; AUER Jan
• Rok publikování: 2002
• Druh: Článek ve sborníku
• Konference: Cells IV
• Fakulta / Pracoviště MU: Lékařská fakulta
• Obor: Morfologické obory a cytologie
• Klíčová slova: induced differentiation; apoptosis; MTT-assay; HL-60 cell line; caffeic acid; retinoic acid; dimethyl sulfoxide
• Popis: The aim of presented study was to investigate possible effect of caffeic acid (CA) in combination with known differentiating agents, all-trans retinoic acid (ATRA) or dimethylsulfoxide (DMSO) respectively, on the HL-60 human myeloid leukemia cell line. Treatment of the HL-60 cells by CA in combination with known differentiation inductors ATRA and DMSO leads to the reduction of cell viability and increased frequency of apoptosis.

Související projekty

• Změny cytoskeletu buněk nádorových linií v průběhu indukované apoptózy v závislosti na stádiu diferenciace