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Difference in angiotensinogen haplotype frequences between chronic heart failure and advanced atherosclerosis patients - new prognostic factor?

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PÁVKOVÁ GOLDBERGOVÁ Monika ŠPINAROVÁ Lenka ŠPINAR Jindřich PAŘENICA Jiří ŠIŠKOVÁ Lenka GROCH Ladislav MÁCHAL Jan VAŠKŮ Anna

Rok publikování 2011
Druh Článek v odborném periodiku
Časopis / Zdroj Physiological Research
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Genetika a molekulární biologie
Klíčová slova RAAS; heart failure; AGT
Popis Numerous association studies have been involved in studying the angiotensinogen (AGT) variants, AGT plasma levels and relations to cardiovascular diseases, such as hypertension, myocardial infarction, coronary heart disease. To investigate a role of AGT G(-6)A and M235T genetic variants for chronic heart failure (CHF) and advanced atherosclerosis (AA), a total of 240 patients with CHF and 200 patients with AA of the Czech origin were evaluated for the study. The study shows the role of polymorphism AGT G(-6)A in genetic background among advanced atherosclerosis patients and chronic heart failure patients (Pg=0.001). This difference was observed also in comparison of AA patients with subgroup of CHF with dilated cardiomyopathy (Pg=0.02; Pa=0.009), and ischemic heart disease (Pg=0.007). The greatest difference between triple-vessel disease and chronic heart failure groups was observed in frequency of GT haplotype (P<0.001) and GGMT associated genotype (P<0.001). Retrospectively, when the subgroups of CHF were compared to AA group (AA vs. IHD with CHF - P < 0.001; and AA vs. DCM - P<0.001) we found the same trend. These results suggest AGT genetic variants as a risk factor for chronic heart failure compared to advanced atherosclerosis disease without heart failure, with a strong difference between IHD patients and chronic heart failure patients with ischemic heart disease, especially in haplotypes and associated genotypes.
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