Prognostic significance of morphological assessment of plasma cells in multiple myeloma.
|Druh||Článek v odborném periodiku|
|Časopis / Zdroj||Neoplasma|
|Fakulta / Pracoviště MU|
|Obor||Onkologie a hematologie|
|Klíčová slova||multiple myeloma; morphology; plasma cells; cytogenetics; prognostic significance; nucleus|
|Popis||Multiple myeloma (MM) is a hematological malignancy caused by clonal proliferation of malignant plasma cells (PC). The aim of the work is to determine prognostic significance of morphological subtypes of PC in relation to overall treatment response, long-term survival and other conventional prognostic parameters. One hundred and thirty-nine newly diagnosed MM patients who underwent autologous transplantation in clinical trials conducted in one center were included. Our work brings valuable prognostic information and correlation with other prognostic factors as well as total treatment response and survival in MM patients who underwent autologous transplantation.|