Informace o projektu
PRECIPITATION OF SCHIZOPHRENIA-LIKE PHENOTYPE BY PRENATAL INFLUENCES: ASSESSING THE ROLE OF THE ENDOCANNABINOID SYSTEM
(ncRNAPain)
- Kód projektu
- 3SGA5789
- Období řešení
- 10/2013 - 9/2016
- Investor / Programový rámec / typ projektu
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Jihomoravský kraj
- SoMoPro
- Granty pro zahraniční vědce
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
- WWW stránky projektu
- https://www.muni.cz/ceitec/research/projects/25465
- Klíčová slova
- Chronická bolest, neuropatická bolest, Komplexní regionální bolestivý syndrom, KRBS, diabetická neuropatie, bolestivá neuropatie, neuroimunitní komunikace, myší model boelsti, patofyziologie bolesti, dráhy bolesti,, mechanizkus bolesti
Epidemiological studies suggest that heavy cannabis consumption during pregnancy may represent an important risk factor to adverse neurodevelopmental outcomes as schizophrenia (SCZ) in adulthood, which symptoms lead to severe personal and social dysfunctions. There is therefore a need to assess new potential neurobiological mechanisms and furthemore to improve therapeutic interventions. Thus, through an innovative approach we will evaluate carrying out molecular, neurochemical and behavioral studies the degree of endocannabinoid signaling modification in the pathophysiology of SCZ as a neurodevelopmental disorder. The aim will be achieved by comparing the effects of prenatal/perinatal Δ9-THC exposure to those induced by the prenatal treatment with the methylazoxymethanol (MAM) acetate, a well validated neurodevelopmental model in rats. Significant attention will be given to the vulnerability of the offspring to develop neonatal behavior deficits as well as a SCZ-like phenotype at different age (from adolescent to adulthood) and how the treatment with novel cannabinoid-related agents could interfere with this phenotype. The structural changes of several brain regions related to the neurotransmitter system alterations will be correlated to the behavioral responses of the animals and the gender-based difference both to develop SCZ-like symptoms and to the pharmacological treatment will be assessed. Despite the limits of an experimental animal model per se, it is expected that results of this proposal will update our knowledge on the pathophysiological bases of SCZ, as a neurodevelopmental disorder, opening new perspectives to ameliorate the present therapeutic protocols.
Publikace
Počet publikací: 15
2024
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Olanzapine, but not haloperidol, exerts pronounced acute metabolic effects in the methylazoxymethanol rat model
CNS NEUROSCIENCE & THERAPEUTICS, rok: 2024, ročník: 30, vydání: 2, DOI
2023
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The Effects of Peripubertal THC Exposure in Neurodevelopmental Rat Models of Psychopathology
International Journal of Molecular Sciences, rok: 2023, ročník: 24, vydání: 4, DOI
2022
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Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia
Biomolecules, rok: 2022, ročník: 12, vydání: 1, DOI
2021
2020
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Metabolic profile of methylazoxymethanol model of schizophrenia in rats and effects of three antipsychotics in long-acting formulation
Toxicology and applied pharmacology, rok: 2020, ročník: 406, vydání: November 2020, DOI
2019
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Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats
Scientific reports, rok: 2019, ročník: 9, vydání: 6062, DOI
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Peripubertal cannabidiol treatment rescues behavioral and neurochemical abnormalities in the MAM model of schizophrenia
2018
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HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals
Journal of cellular physiology, rok: 2018, ročník: 233, vydání: 1, DOI
2017
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Potlačení operantní autoaplikace metamfetaminu ketaminem selhává v MAM modelu schizofrenie
Rok: 2017, druh: Další prezentace na konferencích
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Reactivity to addictive drugs in the methylazoxymethanol (MAM) model of schizophrenia in male and female rats
The World Journal of Biological Psychiatry, rok: 2017, ročník: 18, vydání: 2, DOI